How does Tesamorelin work, and what does it treat?

Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH). It works by stimulating the pituitary gland to naturally produce and release more growth hormone. Originally approved for treating HIV-associated lipodystrophy (abnormal fat distribution), Tesamorelin has also shown benefits in reducing visceral fat, improving metabolism, and supporting overall body composition.

Benefits of Tesamorelin

• Reduces Visceral Fat: Clinically proven to decrease deep belly fat, particularly in patients with lipodystrophy.
• Metabolic Health: Improves lipid profiles, insulin sensitivity, and glucose metabolism.
• Muscle Support: May help preserve lean body mass and support muscle recovery.
• Cognitive Support (Research-based): Emerging data suggest potential benefits for brain health and slowing age-related cognitive decline.

FDA-Approved Uses / Evidence-Based Benefits

• FDA-approved: Treatment of HIV-associated lipodystrophy
• Research-backed: Studies suggest Tesamorelin may have broader applications in metabolic syndrome, aging-related fat redistribution, and cognition, though not yet FDA-approved for these uses.

What types of Tesamorelin treatments are available?

Tesamorelin is available as a subcutaneous injection, typically administered daily. Dosing and administration should be supervised by a healthcare professional to ensure safety and effectiveness.

Tesamorelin Side Effects and Risks

Most common side effects include:

• Redness, itching, or swelling at the injection site
• Muscle aches
• Joint stiffness
• Peripheral edema (mild swelling in hands or feet)
• Increased appetite

Serious but less common risks:

• Elevated blood sugar levels
• Carpal tunnel syndrome
• Increased risk of certain cancers (due to stimulating IGF-1 levels)

Tesamorelin FAQ’s

Who shouldn’t take Tesamorelin?

• Individuals with active cancer
• Those with pituitary gland tumors or a history of pituitary surgery
• Pregnant or breastfeeding women
• Anyone with hypersensitivity to Tesamorelin or mannitol

Will fat return after stopping Tesamorelin?

Yes, studies show that visceral fat may gradually return once treatment is discontinued. Long-term use combined with a healthy lifestyle may help maintain results.